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. 2020 Jul 4;10(4):747–761. doi: 10.1016/j.jcmgh.2020.07.001

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Adoptive transfer of WT T_reg cells attenuates the colitis in CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice. (A) Colonic weight-to-length ratio, (B) Hematoxylin and eosin stain of colon, (C) relative expression of Th1 cytokine IFNγ/TNFα and Th17 cytokine IL-17a/IL-17c in WT mice, CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice and CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice adoptively transferred with WT T_reg cells. Log₂ scale was used on the y-axis. WT indicates wild-type littermate control. KO indicates CD4-Cre^+/TgMettl14^FL/FL conditional knockout. Data are represented as mean ± SD; n = 4–5 mice per group. Data representative of 2 independent experiments with similar results.