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. 2020 Jul 4;10(4):747–761. doi: 10.1016/j.jcmgh.2020.07.001

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Mettl14-deficient T_reg cells have decreased RORγt expression. (A) RORγt percentage in the mesenteric lymph nodes of T_reg and conventional T cells. (B) Representative flow cytometry image showing decreased RORγt expression in T_reg cells. The cells were gated from a parent population of CD25⁺Foxp3⁺ cells. (C) Gating strategy of flow cytometry analysis of RORγt⁺ cells. WT indicates wild-type littermate control. KO indicates CD4-Cre^+/TgMettl14^FL/FL conditional knockout. Data are represented as mean ± SD; n = 8–11 mice per group. Combined data from 3 independent experiments shown.