Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 4;10(4):747–761. doi: 10.1016/j.jcmgh.2020.07.001

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Antibiotic treatment attenuates the colitis in CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice. The CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice were treated with ciprofloxacin + metronidazole for 3 weeks and compared with untreated mice. (A) Colonic weight-to-length ratio, (B) hematoxylin and eosin stain of colon, and (C) relative expression of Th1 cytokine IFNγ/TNFα and Th17 cytokine IL-17a/IL-17c. Log₂ scale was used on the y-axis. (D) Colonic weight-to-length ratio of mice in specific pathogen–free (SPF) facility compared with germ-free facility. (E) Relative expression of Th1 cytokine IFNγ/TNFα and Th17 cytokine IL-17a/IL-17c of mice in germ-free facility. WT indicates wild-type littermate control. KO indicates CD4-Cre^+/TgMettl14^FL/FL conditional knockout. Data are represented as mean ± SD; n = 7–9 mice per group. Combined data from 2 independent experiments shown.

Antibiotic treatment attenuates the colitis in CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice. The CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice were treated with ciprofloxacin + metronidazole for 3 weeks and compared with untreated mice. (A) Colonic weight-to-length ratio, (B) hematoxylin and eosin stain of colon, and (C) relative expression of Th1 cytokine IFNγ/TNFα and Th17 cytokine IL-17a/IL-17c. Log₂ scale was used on the y-axis. (D) Colonic weight-to-length ratio of mice in specific pathogen–free (SPF) facility compared with germ-free facility. (E) Relative expression of Th1 cytokine IFNγ/TNFα and Th17 cytokine IL-17a/IL-17c of mice in germ-free facility. WT indicates wild-type littermate control. KO indicates CD4-Cre^+/TgMettl14^FL/FL conditional knockout. Data are represented as mean ± SD; n = 7–9 mice per group. Combined data from 2 independent experiments shown.