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. 2020 Jul 4;10(4):747–761. doi: 10.1016/j.jcmgh.2020.07.001

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Microbiome analysis of the CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice. (A) Taxonomic composition, (B) alpha diversity, and (C) principal coordinate analysis plot of beta diversity of CD4-Cre^+/TgMettl14^FL/FL conditional knockout mice compared with control animals at week 4 and week 24. WT indicates wild-type littermate control. KO indicates CD4-Cre^+/TgMettl14^FL/FL conditional knockout. n = 4–5 mice per group. (D) m⁶A profiling of CD4⁺ T cells from germ-free mice compared with CD4⁺ T cells from specific-pathogen-free mice. Black color indicates nonsignificant; blue color indicates P < .05 and absolute Log₂ fold change < 1; red color indicates P < .05 and absolute Log₂ fold change > 1. (E) Significant pathways represented by genes with differential m⁶A levels. The top 5 most significant pathways were shown.