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. 2020 Sep 18;4(12):1168–1179. doi: 10.1038/s41551-020-00617-5

Fig. 3. Sensitivity and turnaround time of SENSR.

Fig. 3

a, Sensitivity of SENSR. The target RNA from 220 nM to 0.1 aM was tested. The detection limit is 0.1 aM (approximately six RNA copies in a 100-μl reaction). High linearity suggests that SENSR can be used for the quantification of target RNA. b, Left: turnaround time of SENSR. To check the time required for the SENSR reaction, the incubation time of SENSR was varied. The target RNA of 0.1 aM was detected as early as 30 min. Right: fluorescence of the 30-min SENSR reaction using target RNA at varying concentrations from 0–10 aM. All of the tests were performed with four biological replicates (two-tailed Student’s t-test; ****P < 0.0001; horizontal lines represent means ± s.d).