Table 1.
Characteristics of cervical dystonia cohort by sex and history of mood disorder.
| Groups (N) | All (201) | Women (136) | Men (65) | History of mood disorder (79) | No h/o mood disorder (122) |
|---|---|---|---|---|---|
| CURRENT AGE (Y) | |||||
| Mean (SD) | 61.5 (12.7) | 62.9 (12.2) | 58.5 (13.3) | 59.7 (12.4) | 62.6 (12.8) |
| Median (range) | 62 (31–90) | 63 (33–90) | 60 (31–86) | 62 (33–90) | 63 (31–90) |
| (ns) | (ns) | ||||
| AGE AT CD ONSET (Y) | |||||
| Mean (SD) | 43.6 (12.84) | 45.5 (12.8) | 39.7 (12.1) | 41.2 (12.0) | 45.1 (13.2) |
| Median (range) | 44 (20–79) | 45 (20–79) | 39 (20–65) | 41 (20–66) | 45 (20–79) |
| (p = 0.006) | (p = 0.039) | ||||
| DURATION OF CD (Y) | |||||
| Mean (SD) | 17.9 (11.97) | 17.4 (12.1) | 18.8 (11.7) | 18.5 (13.1) | 17.5 (11.3) |
| Median (range) | 16 (0.16-60) | 15 (0.16–60) | 17 (2–49) | 18 (0.16–60) | 16 (1.5–59) |
| (ns) | (ns) | ||||
| TWSTRS-2 TOTAL | |||||
| Mean (SD) | 30.4 (14.4) | 32 (15) | 27 (12) | 33.6 (15) | 28.7 (13.9) |
| Median (IQR) | 30 (19, 40) | 31 (20,43) | 26 (21,34) | 34 (21, 46) | 29 (19, 37.3) |
| (p = 0.043) | (p = 0.03) | ||||
| TWSTRS-2 PAIN | |||||
| Mean (SD) | 13.6 (9.7) | 14 (10) | 12 (8.7) | 14.9 (9.8) | 12.8 (9.5) |
| Median (IQR) | 14 (5, 20) | 15 (5.3, 22) | 13 (5.0, 18) | 15 (8, 22) | 14 (4, 19) |
| (p = 0.111) | (p = 0.15) | ||||
| TWSTRS-2 SEVERITY | |||||
| Mean (SD) | 10.4 (4.6) | 11 (4.5) | 9.8 (5.0) | 10.8 (4.8) | 10.1 (4.5) |
| Median (IQR) | 11 (7, 13) | 11 (8, 13) | 10 (6, 12) | 10 (7, 14) | 11 (7, 13) |
| (p = 0.16) | (p = 0.65) | ||||
| TWSTRS-2 DISABILITY | |||||
| Mean (SD) | 6.5 (4.9) | 6.9 (4.9) | 5.8 (5.1) | 7.7 (5.1) | 5.8 (4.8) |
| Median (IQR) | 6 (2, 10) | 6.0 (3, 9.5) | 5.0 (2, 9.5) | 7 (4, 11) | 5 (2, 9) |
| (p = 0.114) | (p = 0.0067) | ||||
| BECK ANXIETY INVENTORY | |||||
| Mean (SD) | 11 (11) | 12 (11) | 9.6 (11) | 16.8 (13.1) | 7.1 (7.1) |
| Median (IQR) | 7 (3, 16) | 8 (4, 17) | 6.0 (2, 14) | 13 (8, 26) | 5 (2, 9.3) |
| (p = 0.07) | (p< 0.0001) | ||||
| BECK DEPRESSION INVENTORY | |||||
| Mean (SD) | 11.6 (10.4) | 12 (10) | 10 (10) | 17 (11.6) | 7.9 (7.6) |
| Median (IQR) | 9.0 (3, 18) | 11 (4, 19) | 7.0 (3, 16) | 16 (8, 24) | 6 (2, 12) |
| (p = 0.09) | (p< 0.0001) | ||||
| UTILITY INDEX | |||||
| Mean | 0.712 | 0.6873 | 0.7628 | 0.620 | 0.771 |
| (SD) | 0.259 | (0.2708) | (0.2265) | (0.287) | (0.221) |
| Median | 0.789 | 0.755 | 0.820 | 0.681 | 0.827 |
| IQR | 0.611, 0.902 | 0.586, 0.871 | 0.661, 0.932 | 0.435, 0.852 | 0.676, 0.932 |
| (p = 0.037) | (p< 0.0001) | ||||
| CDIP-58 | |||||
| Mean (SD) | 32.4 (21.9) | 35 (23) | 26 (18) | 38.5 (22.2) | 28.6 (22.2) |
| Median (IQR) | 31 (14, 47) | 35 (17, 49) | 23 (12, 38) | 37 (21, 51) | 24 (11.8, 44) |
| (p = 0.0088) | (p = 0.002) | ||||
Study population characteristics: Demographic characteristics, disease impact and Quality of Life in all (a): 201 cervical dystonia patients, divided (b): by sex (136 women and 65 men) and (c): by a reported history of mood disorder (79 with and 122 without). Measures of dystonia impact by TWSTRS-2 Total, Pain, Severity, Disability, with measures of anxiety (Beck Anxiety Inventory), depression (Beck Depression Inventory) and quality of life (by the Utility Index and CDIP-58). Significant group differences are in bold. Women reported significantly worse TWSTRS-2 Total scores and worse quality of life. Patients with a history of mood disorder, at any time, had ongoing more severe TWSTRS-2 Total and Disability, ongoing more severe depression, anxiety and worse quality of life (TWSTRS, Toronto Western Spasmodic Torticollis Rating Scale; CDIP-58, Cervical Dystonia Impact Profile−58).