Table 2.
Cervical Dystonia Impact Profile-58: Total scores and Subscale scores in 201 patients with cervical dystonia subdivided by sex and history of a mood disorder.
| Groups (N) | ALL (201) | WOMEN (136) | MEN (65) | History of mood disorder (79) | No h/o mood disorder (122) |
|---|---|---|---|---|---|
| CDIP-58 TOTAL | |||||
| Mean (SD) | 32.5 (21.9) | 35 (23) | 26 (18) | 38.5 (22.2) | 28.6 (20.8) |
| Median (IQR) | 31 (15, 47) | 35 (17, 49) | 23 (12, 38) | 37 (21, 51) | 24 (11.8, 44) |
| (p = 0.0088) | (p = 0.002) | ||||
| HEAD AND NECK | |||||
| Mean (SD) | 52.6 (27) | 55 (29) | 48 (23) | 57.8 (25.0) | 49.2 (27.7) |
| Median (IQR) | 54 (33,75) | 57 (33, 78) | 52 (33, 63) | 58 (42, 75) | 50 (25,75) |
| (p = 0.118) | (p = 0.042) | ||||
| PAIN | |||||
| Mean (SD) | 44.9 (30.7) | 47 (32) | 40 (27) | 51.2 (29.6) | 40.9 (30.3) |
| Median (IQR) | 45 (17.5,75) | 48 (20, 75) | 35 (15,63) | 55 (25,75) | 35(15,70) |
| (p = 0.103) | (p = 0.0188) | ||||
| UPPER LIMB | |||||
| Mean (SD) | 31.4 (25.6) | 36 (26) | 22 (22) | 35.9 (25.9) | 28.4 (25) |
| Median (IQR) | 28 (7, 51.5) | 33 (14, 56) | 17 (0, 41) | 33 (14, 56) | 23.5 (5, 48) |
| (p=0.0002) | (p = 0.038) | ||||
| WALKING | |||||
| Mean (SD) | 25.4 (26.3) | 29 (28) | 18 (21) | 28.6 (27.9) | 23.3 (25.2) |
| Median (IQR) | 17 (0, 47) | 21 (1, 50) | 14 (0, 30) | 17 (0, 50) | 17 (0, 39) |
| (p = 0.0127) | (p = 0.234) | ||||
| SLEEP | |||||
| Mean (SD) | 26.7 (29.2) | 30 (30) | 20 (26) | 34 (30.3) | 22 (27.6) |
| Median (IQR) | 19 (0, 50) | 19 (0, 50) | 6 (0, 35) | 31 (0, 56) | 6 (0, 38) |
| (p = 0.037) | (p = 0.0028) | ||||
| ANNOYANCE | |||||
| Mean (SD) | 28.5 (26.7) | 31 (28) | 23 (22) | 36.2 (28.4) | 23.4 (24.4) |
| Median (IQR) | 19 (6, 50) | 22 (6, 50) | 16 (3, 43) | 34 (13, 53) | 16 (3, 38) |
| (p = 0.073) | (p = 0.0014) | ||||
| MOOD | |||||
| Mean (SD) | 23.9 (27.1) | 26 (28) | 19 (24) | 35.2 (30.7) | 16.6 (21.7) |
| Median (IQR) | 11 (0, 39) | 18 (4, 39) | 7 (0, 38) | 25 (7, 57) | 7 (0, 29) |
| (p = 0.065) | (p< 0.0001) | ||||
| PSYCHOSOCIAL | |||||
| Mean (SD) | 34.7 (29.0) | 37 (30) | 30 (26) | 40.8 (30.4) | 30.7 (27.4) |
| Median (IQR) | 28 (10, 54) | 28 (13, 60) | 23 (10, 45) | 33 (18, 68) | 24 (10, 50) |
| (p = 0.177) | (p = 0.0138) | ||||
Cervical Dystonia Impact Profile−58 (CDIP-58): CDIP-58 Total and subscale scores [means, standard deviations (SD) medians and interquartile range (IQR)] in the study population of 201 patients. Comparison of CDIP-58 scores for 136 women and 65 men and also scores for the 79 patients with a history of a diagnosis of a mood disorder compared to 122 patients with no history of mood disorder. Women report significantly worse CDIP-58 Total, “Sleep,” “Upper Limb” and “Walking” subscale scores than men. A history of diagnosed mood disorder is associated with more disease impact in all measures except the “Walking” subscale. Group medians were compared by non-parametric, Mann Whitney testing; significant inter-group comparisons are illustrated in bold.