Table 1.
Summary of Experimentally Observed Changes to the Ca2+ Transient in Normal Healthy Ventricular Myocytes in Rat and Other Species after Addition of IP3 and ET-1
| Cell State | IP3 | ET-1 | |
|---|---|---|---|
| Rat | Amplitude: | r▲(21) r♦(17) | r▲(21) r♦(16) r▲(17) |
| Duration: | – | – | |
| Basal Ca2+: | r♦(17) | r♦(17) | |
| SCTs: | r▲(21) r▲(17) | r▲(21) r▲(17) | |
| Other species | Amplitude: | m▲(20) m♦(73) | h▲(20) m▲(20) |
| Duration: | – | – | |
| Basal Ca2+: | m▲(73) | m▲(20), b▲(22) | |
| SCTs: | – | h▲(20) m▲(20) |
SCT, spontaneous Ca2+ transient. ▲ indicates an increase, ▼ a decrease, and ♦ indicates no significant change reported; r indicates rat, b indicates rabbit, h indicates human, and m indicates mouse; dashes indicate no data found. The model developed in this work is primarily parameterized with rat data.