Table 2.
Multivariable analysis of factors affecting overall survival of allo-HSCT in all patients (N = 7,170).
| Variable | Hazard ratio (95% CI) | p-value |
|---|---|---|
| Age | ||
| Age ≤ median (45 years old) | 1 | |
| Age > median (45 years old) | 1.249 (1.143–1.367) | < 0.0001 |
| Sex | ||
| Female | 1 | |
| Male | 1.151 (1.060–1.250) | < 0.0001 |
| Pre-transplantation depression | ||
| No without anxiety (none) | 1 | |
| Yes without anxiety (depression only) | 1.167 (1.007–1.352) | 0.040 |
| No with anxiety (anxiety only) | 1.038 (0.927–1.162) | 0.519 |
| Yes with anxiety (depression and anxiety) | 1.202 (1.038–1.393) | 0.014 |
| Hematologic disease | ||
| Aplastic anemia | 1 | |
| MDS/MPN | 2.083 (1.611–2.693) | < 0.0001 |
| Leukemia/all lymphomas/Multiple myeloma | 3.063 (2.435–3.853) | < 0.0001 |
| Stem cell source | ||
| Bone marrow | 1 | |
| Peripheral blood | 1.457 (1.268–1.675) | < 0.0001 |
| Previous other malignancy | ||
| No | 1 | |
| Yes | 1.188 (1.052–1.343) | 0.006 |
| Hypertension | ||
| No | 1 | |
| Yes | 1.260 (1.152–1.377) | < 0.0001 |
| Diabetes | ||
| No | 1 | |
| Yes | 1.080 (0.985–1.183) | 0.099 |
| Dyslipidemia | ||
| No | 1 | |
| Yes | 1.030 (0.985–1.123) | 0.509 |
| COPD | ||
| No | 1 | |
| Yes | 1.065 (0.893–1.270) | 0.486 |
| CVD | ||
| No | 1 | |
| Yes | 1.438 (1.206–1.715) | < 0.0001 |
COPD Chronic obstructive pulmonary disease; CVD Cerebro- or cardiovascular disease; HSCT Hematopoietic stem cell transplantation; MDS Myelodysplastic syndrome; MPN myeloproliferative neoplasm.