Table 3.
Multivariable analysis of factors affecting overall survival of allo-HSCT in landmark cohort (N = 6,391).
| Variable | Hazard ratio (95% CI) | p-value |
|---|---|---|
| Age | ||
| Age ≤ median (45 years old) | 1 | |
| Age > median (45 years old) | 1.265 (1.144–1.400) | < 0.0001 |
| Sex | ||
| Female | 1 | |
| Male | 1.196 (1.089–1.312) | < 0.0001 |
| Pre-transplantation depression | ||
| None | 1 | |
| Depression only | 1.155 (0.975–1.369) | 0.0947 |
| Anxiety only | 1.083 (0.955–1.229) | 0.2149 |
| Depression and anxiety | 1.253 (1.061–1.479) | < 0.001 |
| Hematologic disease | ||
| Aplastic anemia | 1 | |
| MDS/MPN | 3.006 (2.156–4.191) | < 0.0001 |
| Leukemia/all lymphomas/Multiple myeloma | 4.785 (3.530–6.487) | < 0.0001 |
| Stem cell source | ||
| Bone marrow | 1 | |
| Peripheral blood | 1.416 (1.215–1.651) | < 0.0001 |
| Previous other malignancy | ||
| No | 1 | |
| Yes | 1.109 (0.960–1.281) | 0.1597 |
| Hypertension | ||
| No | 1 | |
| Yes | 1.208 (1.091–1.338) | < 0.0001 |
| Diabetes | ||
| No | 1 | |
| Yes | 1.104 (0.995–1.225) | 0.0609 |
| Dyslipidemia | ||
| No | 1 | |
| Yes | 1.040 (0.943–1.148) | 0.4536 |
| COPD | ||
| No | 1 | |
| Yes | 1.009 (0.822–1.240) | 0.9288 |
| CVD | ||
| No | 1 | |
| Yes | 1.448 (1.180–1.778) | < 0.0001 |
COPD Chronic obstructive pulmonary disease; CVD Cerebro- or cardiovascular disease; HSCT Hematopoietic stem cell transplantation; MDS Myelodysplastic syndrome; MPN myeloproliferative neoplasm.