Table 5.
Multivariable analysis of factors affecting overall survival of patients receiving allogeneic hematopoietic stem cell transplantation due to leukemia (all leukemia, N = 3,809).
| Variable | Hazard ratio (95% CI) | p-value |
|---|---|---|
| Age | ||
| Age ≤ median (47 years old) | 1 | |
| Age > median (47 years old) | 1.185 (1.068–1.314) | < 0.0001 |
| Sex | ||
| Female | 1 | |
| Male | 1.144 (1.040–1.259) | 0.006 |
| Pre-transplantation depression | ||
| Neither depression nor anxiety (none) | 1 | |
| Depression without anxiety (depression only) | 1.220 (1.031–1.444) | 0.021 |
| Anxiety without depression (anxiety only) | 1.107 (1.031–1.259) | 0.1244 |
| Both depression and anxiety (depression and anxiety) | 1.238 (1.046–1.465) | 0.0132 |
| Stem cell source | ||
| Bone marrow | 1 | |
| Peripheral blood | 1.498 (1.285–1.746) | < 0.0001 |
| Previous other malignancy | ||
| No | 1 | |
| Yes | 1.161 (0.997–1.352) | 0.0545 |
| Hypertension | ||
| No | 1 | |
| Yes | 1.162 (1.046–1.291) | 0.005 |
| Diabetes | ||
| No | 1 | |
| Yes | 0.995 (0.893–1.109) | 0.9288 |
| Dyslipidemia | ||
| No | 1 | |
| Yes | 1.055 (0.954–1.167) | 0.2961 |
| Chronic obstructive pulmonary disease | ||
| No | 1 | |
| Yes | 1.033 (0.832–1.281) | 0.7704 |
| Cerebro- or cardiovascular disease | ||
| No | 1 | |
| Yes | 1.510 (1.224–1.861) | < 0.0001 |