Figure 1.

Final model schematic. The compartment numbers correspond to those in the control stream. The light grey boxes represent parent abemaciclib (LY), the dark grey boxes are for M2, and the black boxes are for M20. A(15), amount in last transit compartment; E_H, extraction ratio of formation of metabolite; F_H,Mx, fraction of parent or metabolite presented to the liver that escapes hepatic metabolism; IV = intravenous; K_a,max, maximum absorption rate constant; K_m,abs, saturable absorption rate constant; K_NY, the first order rate constant from compartment N to compartment Y; K_TR, transit rate constant; LY, abemaciclib; M2, metabolite LSN2839567; M20, metabolite LSN3106726; Q_H, hepatic blood flow; V₁, volume of the central compartment; V_LIV, liver volume.