Table 1.
Cinpanemab population pharmacokinetic parameter estimates
| Parameter | Estimate | SE (%RSE) | Shrinkage |
|---|---|---|---|
| Serum | |||
| tvCL. L/h | 0.00465 | 2.37E−04 (5.1) | |
| tvV1, L | 2.43 | 6.96E−02 (2.9) | |
| tvQ, L/h | 0.0183 | 1.15E−03 (6.3) | |
| tvV2, L | 2.21 | 6.67E−02 (3.0) | |
| Proportional error | 0.0975 | 3.25E−03 (3.3) | |
| CSF | |||
| tvV3, L | 0.175 | ||
| tvK13, 1/h | 7.38E−07 | 7.56E−08 (10.2) | |
| tvK31, 1/H | 0.00732 | 6.16E−04 (8.4) | |
| Body‐weight exponent on V1 | 0.588 | 3.13E−01 (36.8) | |
| Body‐weight exponent on CL | 0.851 | 1.76E−01 (29.9) | |
| Proportional error | 0.296 | 4.04E−02 (1.37) | 9.6 |
| IIV | |||
| tvCL | 0.0645 (25.4) | 0.0161 (25) | 1.1 |
| tvV1 | 0.0192 (13.9) | 0.00508 (26.4) | 3.3 |
| tvQ | 0.0544 (23.3) | 0.0294 (54) | 32.6 |
| tvV2 | 0.0169 (13.0) | 0.00742 (43.9) | 24.0 |
| tvK13 | 0.2 (44.7) | 0.0639 (32) | 12.0 |
Shrinkage is the residual error shrinkage standard deviation percent reported for residual error using EPSSHRINKSD from nonlinear mixed‐effect modeling (NONMEM) output and interparticipant shrinkage for eta reported in percent using ETASHRINKSD from NONMEM output.
%RSE, percent of relative standard errors; CL, systemic clearance; CSF, cerebrospinal fluid; IIV, interindividual variability; K13, rate constant from the central compartment to the cerebrospinal fluid; K31, rate constant from the cerebrospinal fluid compartment to the cerebrospinal fluid compartment; Q, intercompartmental clearance; tv, typical value; V1, volume of distribution of the central compartment; V2, volume of distribution of the peripheral compartment; V3, volume of cerebrospinal fluid compartment.