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. 2020 Sep 17;10:15306. doi: 10.1038/s41598-020-72205-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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T cell responses during acute and convalescent KFDV infection. Absolute numbers of CD4 and CD8 T cells (A,B) (line refers to mean). Frequency of naïve, effector, and central memory CD4 and CD8 T cells (C–I). Representative flow plots for activated CD4 (K) and CD8 (M) T cells in infected patients versus a normal healthy control. Frequency of activated CD4 (J) and CD8 T cells (L). Frequency of proliferating CD8 T cells (N). CD8 + T cells and Ki67 + CD8 T cells expressing effector and memory molecules: granzyme B, perforin, PD1, CTLA-4, BCL-2, and CD45RA (O–T). Statistical significance was determined by one-way ANOVA followed by Tukey`s multiple comparisons test. Graphs were made using GraphPad Prism version 6.01.