. 2020 Sep 17;10:15296. doi: 10.1038/s41598-020-72338-3

Table 2.

Summary of logEC50 ± SE in pulmonary arteries in response to U46619 and mesenteric arteries to ACh in control situation; 20 min incubation with L-NAME; 20 min incubation with LNAME and indomethacin; 20 min incubation with with cocktail: L-NAME, indomethacin, TRAM-34 and apamin; E_max, maximum contractile response; R_max, maximum relaxation response.

Incubation with	ApoE KO-western diet		ApoE KO- standard diet		Sprague Dawley
	n = 8		n = 7		n = 8
	−logEC50 ± SEM	E_max ± SEM	−logEC50 ± SEM	E_max ± SEM	−logEC50 ± SEM	E_max ± SEM
Pulmonary artery
Control situation	7.06 ± 0.15	83.34 ± 9.01	6.92 ± 0.11	97.64 ± 7.73	6.78 ± 0.15	95.90 ± 10.22
L-NAME	7.08 ± 0.12	141.3 ± 10.61	7.2 ± 0.13	145.2 ± 10.91	7.07 ± 0.13	141.0 ± 11.54
L-NAME + indomethacin	7.36 ± 0.10	145.7 ± 8.29	7.05 ± 0.12	126.0 ± 9.74	6.77 ± 0.21	121.3 ± 15.90
Cocktail	7.33 ± 0.08	141.3 ± 7.33	7.16 ± 0.19	121.8 ± 8.18	6.83 ± 0.18	110.8 ± 12.50

	−logEC50 ± SEM	R_max ± SEM	−logEC50 ± SEM	R_max ± SEM	−logEC50 ± SEM	R_max ± SEM
Mesenteric artery
Control situation	6.89 ± 0.15	59.61 ± 4.70	6.96 ± 0.12	61.81 ± 3.51	7.16 ± 0.11	59.28 ± 3.47
L-NAME	6.54 ± 0.57	20.42 ± 2.92	7.12 ± 0.26	18.90 ± 1.94	6.08 ± 0.62	48.40 ± 12.84
L-NAME + indomethacin	6.95 ± 0.83	27.78 ± 4.48	7.75 ± 0.28	27.37 ± 2.80	7.29 ± 0.22	32.70 ± 3.00
Cocktail	8.045 ± 0.22	18.21 ± 1.51	7.58 ± 0.10	18.87 ± 0.82	7.39 ± 0.13	15.99 ± 0.90