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. 2020 Sep 17;11(9):766. doi: 10.1038/s41419-020-02938-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Images of BxPC-3 cells or shNrf2 BxPC-3 cells xenograft tumours at the end of the treatment. BALB/C mice (n = 5) were injected subcutaneously with 1 × 10⁷ BxPC-3 cells. These mice were sacrificed after 12 days of treatment with or without anlotinib (4 mg/kg), and the tumours were dissected and photographed. b The weights of the BxPC-3 cell xenograft tumours at the end of the treatment (***p < 0.001). c Tumour volumes in BALB/C mice during the 12-day treatment (mean ± SEM, *p = 0.0339, ***p < 0.001). d–f (d) Image, (e) weight and (f) volume (mean ± SEM, *, p = 0.0389, ***, p < 0.001) of PANC-1 or shNrf2 PANC-1 cell xenograft tumours. g After treatment as indicated above, Ki-67 protein expression was detected in sections of xenograft tumours by immunohistochemical analysis (the length of the bar is 100 μm).