Table 1.
Highly expressing and/or regulated sex-dependent DEGs in sensory neurons.
| Gene ID | Female (RPKM) | Male (RPKM) | FC | Ganglia | Functional cluster |
|---|---|---|---|---|---|
| LTbR | 9.4134 | 2.3504 | 6.1 | DRG-per | Immune processes |
| Pdgfb | 14.3196 | 4.5201 | 4 | DRG-per | Growth factor and receptors |
| Ier5 | 12.1479 | 4.5225 | 2.7 | DRG-per | Transcription |
| Il33 | 20.2942 | 8.0692 | 2.5 | DRG-per | Immune processes |
| Vtn | 39.8644 | 15.8489 | 2.5 | DRG-per | Cell adhesion |
| Cd74 | 84.1816 | 38.4553 | 2.2 | DRG-per | Immune processes |
| Tnfrsf11a | 13.3066 | 6.4695 | 2.1 | DRG-per | Immune processes |
| Tnfrsf1a | 25.8606 | 12.3243 | 2.1 | DRG-per | Immune processes |
| Notch3 | 19.2212 | 3.5448 | 5.5 | TG-per | Transcription activator |
| Icam1 | 25.7730 | 7.6667 | 3.5 | TG-per | Extracellular matrix |
| Cntfr | 9.7744 | 3.3522 | 2.9 | TG-per | Growth factor and receptors |
| Col1a2 | 55.3372 | 19.8403 | 2.8 | TG-per | Extracellular matrix |
| Ephb6 | 34.2972 | 12.7276 | 2.7 | TG-per | Transcription |
| Socs3 | 19.2212 | 7.3801 | 2.6 | TG-per | Transcription |
| Cd74 | 101.0626 | 41.2613 | 2.5 | TG-per | Immune processes |
| Nts | 1.5979 | 9.6273 | 6.3 | DRG-per | Ligand |
| Cbr3 | 5.0846 | 23.7600 | 4.2 | DRG-per | Oxidation–reduction |
| Rpl13 | 9.8586 | 28.0830 | 3 | DRG-per | Translation |
| Med27 | 8.5363 | 22.0349 | 2.8 | DRG-per | Transcription |
| Ndufa8 | 69.0643 | 164.7326 | 2.4 | DRG-per | Cellular respiration |
| Bud31 | 26.8360 | 87.8333 | 3.2 | TG-per | Transcription |
| Cycs | 2.8780 | 6.4099 | 3.0 | TG-per | Oxidation–reduction |
| Glrx3 | 6.0700 | 16.7323 | 2.7 | TG-per | Oxidation–reduction |
| Rpl15 | 24.2493 | 57.6599 | 2.5 | TG-per | Translation |
| Psmd10 | 11.2953 | 25.5359 | 2.3 | TG-per | Proteasome complex |
| Habp4 | 37.4722 | 9.8522 | 3.8 | DRG-WGA | Transcription |
| Ajuba | 16.1277 | 4.8867 | 3.3 | DRG-WGA | Protein complexes |
| Cd74 | 8.0827 | 2.6312 | 3.1 | DRG-WGA | Immune processes |
| Sox10 | 61.8918 | 19.7046 | 3.1 | DRG-WGA | Transcription |
| Fbxo31 | 82.1134 | 35.7397 | 2.3 | DRG-WGA | Proteasome complex |
| Fam176b | 68.1104 | 32.7675 | 2.1 | DRG-WGA | ??? |
| Tmem173 | 6.9528 | 27.0744 | 4 | DRG-WGA | Immune processes |
| Alkal2 | 55.0269 | 139.9446 | 2.5 | DRG-WGA | Ligand for trk receptors |
| Arxes2 | 82.6752 | 172.6092 | 2.2 | DRG-WGA | Nervous system develop |
| Adamts8 | 6.0444 | 13.3836 | 2.1 | DRG-WGA | Enzyme |
| Pkib | 21.9057 | 47.3196 | 2.1 | DRG-WGA | Channel regulator |
FC fold change; italic font shows male-selective and bold font represents female-selective DEGs. DRG-per are DRG neurons enriched by Percoll; TG-per is TG neurons enriched by Percoll; DRG-WGA are neurons innervating hindpaw skin and thigh muscle. ???—unknown functional cluster.