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. 2020 Sep 17;11(9):765. doi: 10.1038/s41419-020-02916-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a HLF1 stimulated with or without TGFβ1 were treated with 10 and 30 nM of CUDC-907 for 12 h. Cells were then stained with PI and analyzed by FACS. CUDC-907 caused a significant increase in the G1-S peak in all cell lines tested at the 12-h time-point after drug treatment. b Histogram representation of the percentage of cells in different cell-cycle phases. c HLF1 were treated with CUDC-907 at dose ranging from 10 to 200 nM. Cells were then stained with Annexin V/PI and analyzed by FACS. d HLF1 stimulated with TGFβ1 were treated with 10 and 30 nM of CUDC-907. Cells were then stained with Annexin V/PI and analyzed by FACS. e Histogram representation of the percentage of cells in different apoptosis phases in c. f Histogram representation of the percentage of apoptosis cells in d. Error bars are ±SD. *, **, *** represent 907 treatment groups compared with DMSO group, respectively. *P < 0.05; **P < 0.01; ***P < 0.001. #, ##, ### represent T + 907 treatment groups compared with TGFβ1 group, respectively. ^#P < 0.05; ^##P < 0.01; ^###P < 0.001.