Table 2.
The list of targets and active compounds of Tao-Hong-Si-Wu-Tang formula against ONFH.
| TCMSP ID | Chemical compound | Herb source | Target |
|---|---|---|---|
| MOL000006 | Luteolin | Carthami Flos | PTGS2, PRSS1, RELA, VEGFA, CCND1, MMP2, RB1, JUN, IL6, MMP1, PCNA, MCL1, PTGES, MET |
| MOL000296 | Hederagenin | Persicae Semen | ADH1C, SCN5A, PTGS2 |
| MOL000358 | Gibberellin 7 | Paeoniae Radix Alba, Angelicae Sinensis Radix, Carthami Flos, Persicae Semen | PTGS2, SCN5A, CHRM4, ADRA1A, OPRM1, JUN, PRKCA |
| MOL000422 | Kaempferol | Paeoniae Radix Alba, Carthami Flos | PTGS2, PRSS1, ACHE, F7, CALM1, RELA, JUN, MMP1, STAT1, VCAM1, CYP1B1, ALOX5, HAS2, AHR, NR1I3 |
| MOL000449 | Stigmasterol | Rehmanniae Radix Praeparata, Angelicae Sinensis Radix, Carthami Flos | ADH1C, PTGS2, SCN5A, ADRA1A |
| MOL000492 | (+)-catechin | Paeoniae Radix Alba | PTGS2, CALM1, HAS2 |
| MOL000493 | Campesterol | Persicae Semen | PTGS2 |
| MOL001323 | Sitosterol alpha1 | Persicae Semen | PTGS2, ADH1C |
| MOL001328 | 2,3-didehydro GA70 | Persicae Semen | PTGS2, PRSS1 |
| MOL001329 | 2,3-didehydro GA77 | Persicae Semen | PTGS2 |
| MOL001340 | GA120 | Persicae Semen | PTGS2 |
| MOL001352 | GA54 | Persicae Semen | PTGS2, CALM1 |
| MOL001355 | GA63 | Persicae Semen | PTGS2 |
| MOL001358 | Gibberellin 7 | Persicae Semen | PTGS2 |
| MOL001361 | GA87 | Persicae Semen | PTGS2 |
| MOL001368 | 3-O-p-coumaroylquinic acid | Persicae Semen | PTGS2, CALM1 |
| MOL001494 | Mandenol | Chuanxiong Rhizoma | PTGS2 |
| MOL001924 | Paeoniflorin | Paeoniae Radix Alba | IL6, CD14, LBP |
| MOL002135 | Myricanone | Chuanxiong Rhizoma | SCN5A, PTGS2, F7 |
| MOL002140 | Perlolyrine | Chuanxiong Rhizoma | PTGS2 |
| MOL002157 | Wallichilide | Chuanxiong Rhizoma | PTGS2, NR3C1 |
| MOL002694 | 4-[(E)-4-(3,5-dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene) but-2-enylidene]-2,6-dimethoxycyclohexa-2,5-dien-1-one | Carthami Flos | PTGS2 |
| MOL002695 | Lignan | Carthami Flos | PTGS2, CALM1 |
| MOL002710 | Pyrethrin II | Carthami Flos | PTGS2 |
| MOL002712 | 6-hydroxykaempferol | Carthami Flos | PTGS2, PRSS1 |
| MOL002714 | Baicalein | Carthami Flos | PTGS2, PRSS1, CALM1, RELA, VEGFA, AHR, EGLN1, APOD |
| MOL002717 | qt_carthamone | Carthami Flos | PTGS2 |
| MOL002721 | Quercetagetin | Carthami Flos | PTGS2, PRSS1 |
| MOL002757 | 7,8-dimethyl-1H-pyrimido[5,6-g]quinoxaline-2,4-dione | Carthami Flos | PTGS2 |
| MOL002773 | Beta-carotene | Carthami Flos | VEGFA, MMP2, JUN, PTGS2, MMP1, CAV1, GJA1 |