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. 2020 Sep 17;11(9):770. doi: 10.1038/s41419-020-02974-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Six-week-old male mice were fed a high-fat diet for 8 weeks, and then treated with or without 200 mg/kg/d GP2 for 5 weeks (n = 4). a, b Sobs index analysis of the gut microbiome of HFD-fed mice after oral administration of GP2 for 5 weeks. c Principal coordinate analysis of gut microbiota composition based on unweighted UniFrac. d Pie charts of the average relative abundance of the gut microbiota in the feces at the phylum level. e Heatmap depicting the relative abundance of the microbiota in the feces at the genus level as in d. The results are shown as the mean ± s.e.m., ***P < 0.001 compared with vehicle.