Table 1.
Characteristics of included studies measuring peripheral blood markers.
| No. | Study and year | Country or region | Sample size | Gender (M/F) | Mean age (years) | CAG-RN | OS markers measured | Sample source | Diagnosis criteria |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Stoy 2005 | UK | HD 11 | 3/8 | NA | NA | MDA and 4-hydroxynonenal; tryptophan metabolites | Serum | NA |
| HC 15 | 4/11 | NA | — | ||||||
| 2 | Hersch 2006 | USA | HD 32 | NA | NA | NA | 8-OHdG | Serum | UHDRS |
| HC 32 | |||||||||
| 3 | Chen 2007 | Taiwan | HD 16 | 9/7 | 48.4 | 45.0 | MDA; 8-OHdG; SOD; and GPx | Plasma, serum, and erythrocyte | UHDRS |
| HC 36 | 19/17 | 53.0 | — | ||||||
| 4 | Klepac 2007 | Croatia | HD 19 | 14/5 | 46 | 45.0 | MDA; GSH; and SOD | Plasma | UHDRS |
| HC 47 | 31/16 | 41 | — | ||||||
| 5 | Duran 2010 | Spain | HD 24 | 10/14 | 48.4 | 45.1 | LPO | Plasma | UHDRS |
| HC 60 | 30/30 | 48.0 | — | ||||||
| 6 | Leoni 2011 | Italy | HD 127 | 57/70 | 52.1 | 44.6 | Cholesterol | Plasma | UHDRS |
| HC 134 | 67/68 | 48.2 | — | ||||||
| 7 | Salvatore 2011 | Italy | HD 17 | 10/7 | 48.8 | 44.8 | Cholesterol; LDL; and HDL | Blood | UHDRS |
| HC 17 | 10/7 | 49.2 | — | ||||||
| 8 | Tunez 2011 | Spain | HD 19 | 9/10 | 43.5 | 46.5 | 8-OHdG; LPO; GSH; SOD; GPx; cholesterol; HDL; LDL; and triglycerides | Plasma, erythrocyte | UHDRS |
| HC 19 | 8/11 | 42.2 | — | ||||||
| 9 | Ciancarelli 2014 | Italy | HD 18 | 13/5 | 51.1 | NA | 8-OHdG; SOD; cholesterol; HDL; and triglycerides | Serum, plasma | UHDRS |
| HC 10 | 4/6 | 50.0 | — | ||||||
| 10 | Wang 2014 | USA | HD 8 | 5/3 | 57.6 | 42.5 | Cholesterols; HDL; LDL; and triacylglycerols | Plasma | NA |
| HC 8 | 5/3 | 57.0 | — | ||||||
| 11 | Peña-Sánchez 2015 | Cuba | HD 14 | 8/6 | 50.0 | 45.0 | Cholesterol; triglycerides; MDA; GSH; SOD; and GPx | Serum | UHDRS |
| HC 29 | 12/17 | 48.0 | — | ||||||
| 12 | Nielsen 2016 | Denmark | HD 70 | 36/33 | 51.5 | 43.3 | Cholesterol | Blood | UHDRS |
| HC 40 | 18/22 | 41.4 | — |
HD: Huntington's disease; HC: healthy controls; M/F: male/female; CAG-RN: cytosine-adenine-guanine repeat number; OS: oxidative stress; MDA: malondialdehyde; LPO: lipid peroxidation products; 8-OHdG: 8-hydroxyguanosine; GSH: glutathione; GPx: glutathione peroxidase; SOD: superoxide dismutase; LDL: low-density lipoprotein; HDL: high-density lipoprotein; UHDRS: Unified Huntington's Disease Rating Scales; NA: not available.