Table 2.
Summary of comparative outcomes for measurements of blood marker levels.
| Marker | No. of studies | No. with HD/HC | Main effect | Heterogeneity | Publication bias | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Hedges g (95% CI) | p value | Q statistic | df | p value | I 2 statistic | Egger's intercept | p value | |||
| LPO | 6 | 103/206 | 0.883 (0.637–1.130) | ≤0.001 | 2.221 | 5 | 0.818 | 0 | 2.65081 | 0.10766 |
| 8-OHdG | 3 | 52/65 | 1.727 (0.489–2.965) | 0.006 | 17.520 | 2 | <0.001 | 88.585 | -0.65530 | 0.98446 |
| GSH | 3 | 52/95 | -0.611 (-1.016–-0.207) | 0.003 | 2.690 | 2 | 0.261 | 25.639 | 2.80380 | 0.84614 |
| GPx | 3 | 49/84 | 2.026 (0.570–3.482) | 0.006 | 21.812 | 2 | <0.001 | 90.831 | 15.55092 | 0.27934 |
| SOD | 3 | 49/84 | -1.239 (-2.753–0.274) | 0.109 | 28.130 | 2 | <0.001 | 92.890 | -15.59612 | 0.29130 |
| Cholesterol | 7 | 273/257 | 0.020 (-0.395–0.435) | 0.925 | 24.093 | 6 | 0.001 | 75.097 | -1.37103 | 0.44288 |
| HDL | 4 | 62/54 | -0.435 (-0.898–0.028) | 0.066 | 4.656 | 3 | 0.199 | 35.565 | -2.99853 | 0.54086 |
| LDL | 3 | 44/44 | -0.922 (-2.616–0.772) | 0.286 | 24.681 | 2 | <0.001 | 91.897 | -7.49790 | 0.40826 |
| Triglycerides | 4 | 59/66 | 0.486 (-0.977–1.949) | 0.515 | 40.437 | 3 | <0.001 | 92.581 | 12.84671 | 0.11963 |
df: degrees of freedom; HD: Huntington's disease; LPO: lipid peroxidation products; 8-OHdG: 8-hydroxyguanosine; GSH: glutathione; GPx: glutathione peroxidase; SOD: superoxide dismutase; LDL: low-density lipoprotein; HDL: high-density lipoprotein.