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. 2020 Sep 17;10:15253. doi: 10.1038/s41598-020-72190-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis on vCSF-cfmtDNA integrity in NDDs and matched controls. Boxplots of vCSF-cfmtDNA integrity in NDD, showing (a) vCSF-cfmtDNA deletion level in NDDs and matched controls, (b) the comparative total vCSF-cfmtDNA heteroplasmic mutation rate in each NDD and matched controls, (c) the comparative non-synonymous vCSF-cfmtDNA heteroplasmic mutation rate in each NDD and matched controls and (d) the vCSF-cfmtDNA Ka/Ks(+ 1) for in each NDD and matched controls. Where AD = Alzheimer’s Disease, DLB = dementia with Lewy bodies, PSP = progressive supranuclear palsy, MND = motor neuron disease, FTD/VD = frontotemporal lobar dementia/vascular dementia and PD = Parkinson’s disease. Boxes show median, 25th and 75th percentile and whiskers show 95% confidence interval.