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. 2020 Sep 17;10:15271. doi: 10.1038/s41598-020-72227-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The OA post-traumatic DMM model was characterized by the presence of mechanical allodynia. Mechanical allodynia (A), and alterations in locomotor activity (B) and gait pattern (C) were assessed 4, 6, 8, 10 and 12 weeks after the knee joint traumatic lesion. The Von Frey data analysis showed that DMM mice presented increased mechanical allodynia when compared with sham-operated, starting at week 8. No effects were observed in the locomotor activity. A decrease in the ITS was observed in the DMM mice. Results are presented as mean ± SEM, n = 5 in the control group and n = 8 in the sham-operated and DMM groups. *Indicates differences between sham-operated and DMM groups; ^#indicates differences when compared with non-operated group; ^&indicates differences when compared with week 4; *p < 0.05; **p < 0.01; ***p < 0.001; ^#p < 0.05; ^##p < 0.01; ^&p < 0.05; ^&&p < 0.01. ITS intermediate toe spread, PL print length, TS toe spread.