Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;10:15271. doi: 10.1038/s41598-020-72227-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

CGRP expression was increased in the DRG after the induction of the OA post-traumatic DMM model. The expression of TrkA, TRPV1, and CGRP (A) was assessed in the DRG 12 weeks post-surgery; quantitative analyses of the staining intensity were performed. The expression of NPY in DRG and the infiltration of DRG by macrophages were also assessed at the same time point of disease progression (B). Increased expression levels of CGRP in the DRG of DMM mice were observed at 12 weeks after the knee traumatic lesion. No differences were observed in the expression of TrkA and TRPV1 between DMM and sham-operated mice. No expression of NPY was found in the DRG, and no macrophages were infiltrating the DRG 12 weeks after DMM surgery. Results are presented as mean ± SEM, n = 5 per group. *p < 0.05. Scale bar = 50 μm.