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. 2020 Sep 17;10:15295. doi: 10.1038/s41598-020-72247-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum LBP is increased in patients with ALS and correlates with disease burden and disease progression rate. (A) LBP was increased in the serum of all patients compared with HC (*p < 0.001). (B) LBP was elevated in fast (*p < 0.001) and slowly (*p < 0.001) progressing patients compared with HC. LBP was elevated in the fast progressing patients compared with slowly progressing patients (p < 0.001). (C) Serum LBP positively correlated with the patient’s burden of disease. (D) Serum LBP positively correlated with the patient’s disease progression rate. (E) There was a positive correlation between LBP and sCD14. (F) Serum LBP levels were an accurate indicator of disease progression rates.