Skip to main content
. 2020 Sep 15;153(11):115101. doi: 10.1063/5.0020458

FIG. 1.

FIG. 1.

Structure and sequence of SARS-CoV-2 PLpro in comparison to SARS-CoV and MERS-CoV PLpros. (a) X-ray crystal structure of SARS-CoV PLpro (in gray; PDB 2FE813), MERS-CoV PLpro (in salmon; PDB 4RNA23) overlaid on SARS-CoV-2 PLpro (in green; PDB 6W9C). (b) The thumb (residues 63–182), palm (residues 241–314), and fingers (residues 183–240) subdomains of SARS-CoV-2 PLpro are shown in different colors. The Cys and His residues are represented by yellow and blue spheres, respectively. The active site is also shown in a zoomed-in view, with the catalytic His, Cys, and Asp side chains represented by the stick model and the BL2 loop (G266–G271) colored red. (c) Sequence similarity and identity between SARS-CoV, SARS-CoV-2, and MERS-CoV PLpros. The sequence alignment of a part of the thumb and palm subdomains is shown.