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. 2020 Sep 15;153(11):115101. doi: 10.1063/5.0020458

FIG. 5.

FIG. 5.

Comparison of the BL2 loop conformation across the three PLpros and between low and high pH. (a) Probability distributions of the Cα distance between Tyr269/268 and Asp165/164 in SARS-CoV/CoV-2, and between Thr274 and Asp164 in MERS-CoV PLpro at pH 7.5. (b) Probability distribution of the Cα distance between Tyr268 and Asp164 in SARS-CoV-2 PLpro at pH 4.5 (red) and 7.5 (blue). (c) Overlaid crystal structures showing the closed (red; pH 4.5 structure) and open (blue; pH 7.5 structure) BL2 conformations.