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. 2020 Sep 18;21:239. doi: 10.1186/s12931-020-01498-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Representative images of the immunohistochemical stainings for cell-bound MUC1 in bronchial biopsy samples. Intensity of the expression was designated as negative, faint, moderate, strong or very strong, and the extent of the positive staining was estimated from 0 to 100% in each cell type present in the airways. Expression of MUC1 in cells suggesting basal cell phenotype in the large airways of a Never-smoker with normal lung functions (a), a Smoker with normal lung function (b), MUC1 expression in basal cells of an ex-smoker with COPD (c) and a Smoker with COPD (d)