Table 1.
Description of Selected Dental Stem Cell Types
| Cell type | Location | Properties | Markers |
|---|---|---|---|
| DPSCs | Dental pulp | First dental SC identified. Share commonalities with neural stem cells. Indicate neurogenic and vascular endothelial differentiation potential.11,12 | STRO-1, CD146, OCT4 |
| SHED | Exfoliated deciduous teeth | Faster proliferation, more immature DPSC, high CFUs. Suggested to be incapable of osteoblast or osteocyte differentiation.13,14 | STRO-1, CD146, OCT4 |
| SCAP | Apical papilla | Differentiable to odontoblast-like cell type. | STRO-1, CD24, CD29 |
| Comparable osteogenic and dentinogenic potential to DPSCs, less adipogenic potential.15 | |||
| PDLSCs | Periodontal ligament | Differentiate into cementoblast-like cells. Potential regeneration of periodontal structures.16 | STRO-1, CD146, tendon-specific TF |
| HOMSCs | Oral mucosa | Isolated from oral mucosa and gingiva; may include multiple cell types. Demonstrate MSC-like tri-lineage differentiation.17 | CD13, CD29, CD44, CD73, CD90, CD105, CD146, CD166, STRO-1, SSEA-4 |
| DFPCs | Dental follicle | Heterogeneous population of mixed cell phenotypes. Demonstrate osteogenic potential.18,19 | CD13, CD29, CD72, CD90, CD105, CD106, CD166, Notch1, STRO-1, Nestin |
| hABMSCs | Alveolar bone | Demonstrate significant bone-forming capacity and MSC-like tri-lineage differentiation.20 | CD73, CD90, CD105, CD146, CD166, STRO-1 |
CFU, colony forming unit; DFPCs, dental follicle precursor cells; DPSCs, dental pulp stem cells; hABMSCs, human alveolar bone-derived mesenchymal stem cells; HOMSCs, human oral mucosa stem cells; MSC, mesenchymal stem cell; PDLSCs, periodontal ligament stem cells; SC, stem cell; SCAP, stem cells of the apical papilla; SHED, stem cells of human exfoliated deciduous teeth.