Table 1.
Comparison of clinical characteristics in patients with de novo DLB and PD
| Item | PD (N = 75) | DLB (N = 24) | p value a |
|---|---|---|---|
| Age (years) | 72.2 ± 9.4 | 80.0 ± 5.0 | 0.001 |
| Gender (male/female) | 27/48 | 18/6 | 0.001 |
| Symptom duration (years) | 1.6 ± 1.6 | 1.9 ± 1.7 | 0.296 |
| UPDRS motor score | 20.3 ± 10.9 | 21.3 ± 10.8 | 0.236 |
| Subtype (akinetic-rigid/tremor-dominant or mixed) | 45/30 | 19/5 | 0.087 |
| Olfaction | 4.1 ± 2.8 | 2.4 ± 2.2 | 0.010 |
| Mini-mental state examination | 27.7 ± 2.2 | 20.0 ± 4.7 | 0.001 |
| Frontal assessment battery | 15.1 ± 2.8 | 10.2 ± 3.4 | 0.001 |
| MIBG H/M ratio delay | 1.44 ± 0.33 | 1.22 ± 0.39 | 0.001 |
| BP fall in head-up tilt-table test (HUT) (mmHg) | 23.6 ± 20.0 | 48.5 ± 23.6 | 0.001 |
| Prevalence of OH (−/+) | 36/39 | 1/23 | 0.001 |
| Norepinephrine at rest in supine position in HUT (μg/ml) | 217.9 ± 88.2 | 172.8 ± 82.5 | 0.009 |
| Nocturnal fall in BP in ABPM (%) | 8.5 ± 9.4 | −4.4 ± 12.6 | 0.001 |
| ABPM type (dipper/non dipper or riser type) | 37/38 | 4/20 | 0.005 |
| BP fall in postprandial hypotension (mmHg) | 18.4 ± 13.1 | 32.8 ± 17.2 | 0.001 |
| Postprandial hypotension (−/+) | 42/33 | 6/18 | 0.008 |
| BP in supine hypertension (mmHg) | 134.8 ± 21.5 | 147.5 ± 19.2 | 0.011 |
| Supine hypertension (−/+) | 45/30 | 10/14 | 0.116 |
| Neurogenic supine hypertension (−/+) | 56/19 | 12/12 | 0.013 |
| Constipation (−/+) | 25/50 | 1/23 | 0.008 |
a Wilcoxon rank sum test and Lepage analysis for continuous variables and χ2 test for binary variables
UPDRS Unified Parkinson’s Disease Rating Scale, MIBG 123I-metaiodobenzylguanidine, H/M: ratio of the average pixel count in the heart (H) to that in the mediastinum (M), ABPM 24-h ambulatory blood pressure monitoring