Table 3.
Independent risk factors and assigned scores used to build the predictive scoring model for positive follow-up blood culture in gram-negative bacteraemia, according to eradicable and non-eradicable sources of infection
| Eradicable source of infection | ||||
|---|---|---|---|---|
| Beta-coefficient | Odds ratio (95% CI) | p-value | Assigned score | |
| ESBL-producing microorganism infection | 1.001 | 2.720 (1.179–6.271) | 0.019 | + 1 |
| CRBSI | 1.374 | 3.95 (1.522–10.255) | 0.005 | + 1 |
| Unfavourable treatment responsea | 0.802 | 2.229 (1.262–3.937) | 0.006 | + 1 |
| qSOFA score ≥ 2 on the day of FUBC | 0.864 | 2.371 (1.034–5.438) | 0.041 | + 1 |
| Effective antibiotics administration before the day of FUBC | −1.007 | 0.365 (0.164–0.814) | 0.014 | −1 |
| Adequate source control before the day of FUBC | −1.983 | 0.138 (0.064–0.294) | 0.000 | −2 |
| Non-eradicable source of infection | ||||
| ESRD on HD | 1.406 | 4.081 (1.331–12.515) | 0.014 | + 1 |
| Unfavourable treatment responsea | 0.802 | 2.229 (1.262–3.937) | 0.006 | + 1 |
| Effective antibiotics administration before the day of FUBC | −2.015 | 0.133 (0.069–0.258) | 0.000 | −2 |
CI Confidence interval, ESBL Extended-spectrum beta-lactamase, CRBSI Catheter-related bloodstream infection, qSOFA Quick sequential organ failure assessment, FUBC Follow-up blood culture, ESRD End-stage renal disease, HD Haemodialysis
aUnfavourable treatment response was defined as positivity for at least 2 variables among the presence of fever, aggravated leucocytosis, and no decrease of C-reactive protein on the day of FUBC