Table 4.
Receiver operating characteristics and predictability of scoring models for positive follow-up blood culture in gram-negative bacteraemia, according to the various cut-off values
| AUC (95% CI) | Cut-off | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|
| Eradicable source of infectiona | 0.861 (0.806–0.916) | −2 | 88.5% | 67.0% | 27.7% | 97.6% |
| −1 | 76.9% | 82.1% | 38.1% | 96.1% | ||
| 0 | 46.2% | 95.6% | 60.0% | 92.6% | ||
| 1 | 17.3% | 99.3% | 75% | 90.63% | ||
| 2 | 3.8% | 100% | 100% | 87.9% | ||
| Non-eradicable source of infection | 0.792 (0.724–0.861) | −2 | 83.9% | 58.4% | 14.4% | 97.6% |
| −1 | 58.9% | 86.9% | 27.3% | 96.2% | ||
| 0 | 39.3% | 95.5% | 42.3% | 95.0% | ||
| 1 | 3.6% | 100.0% | 100.0% | 92.5% |
AUC Area under the curve, CI Confidence interval, PPV Positive predictive value, NPV Negative predictive value
aGram-negative bacteraemia in which the primary source of infection could be removed, e.g. removal of a central venous catheter or other endovascular device, drainage of a dilated bile duct or hydronephrosis, surgical debridement of skin and soft tissue infection or osteomyelitis, drainage or removal of an intra-abdominal abscess, or drainage of empyema or a lung abscess