Table I.

Cytokines, chemokines and metabolites identified to be associated with M2-like TAMs recruitment in the TME.

Cytokines	Chemokines	Metabolites	Cells
FGF-2,VEGF, EMAP2, CSF1, PDGF, IL-25, TGF-β, HIF-1α, CSF2, IL-4, IL-6, IL-10, TNF-α, NF-κB, EGF, P2Y2, HMGB1, Fizz1, ADM, SEMA3A, TLR-4, MMPs, STAT3 and STAT6, PG, serine protease, COX2, cathepsins B and S, endothelin, oncostatin M, eotaxin, C1q, arginase	CCL2, CCL3, CCL5, CCL4, CCL22, CCL17, CCL18, CCL20, CCR5, CX3CL1, CX3CL5, CX3CL6, CXCL8, CX3CL8, CX3CL, CX3CR1 CX3CL16, CXCL12	High lactate, low pH, succinate, LPC, S1P, high kynurenine, lipid accumulation, ribosomal protein S19, and nucleotides such as ATP and UTP	Apoptotic tumor cells, adipocyte, tumor cell, endothelial cell, fibroblasts and cancer stem cells

TAM, tumor-associated macrophage; TME, tumor microenvironment; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor; EMAP2 (AIMP1), aminoacyl tRNA synthetase complex interacting multifunctional protein 1; CSF, colony stimulating factor; IL, interleukin; PDGF, platelet derived growth factor; P2Y2, purinergic receptor P2Y2; HMGB1, high-mobility group box-1; TGF, transforming growth factor; HIF, hypoxia inducible factor; TNF, tumor necrosis factor; TLRs, toll-like receptor; CCL, C-C motif chemokine ligand; NF-κB, nuclear factor kappa B; FIZZ1, found in inflammatory zone 1; ADM, adrenomedullin; SEMA3A, semaphorin 3A; STAT, signal transducer and activator of transcription; PG, progesterone; COX2, cytochrome c oxidase subunit II; C1q, complement C1q; CXCL, C-X-C motif chemokine ligand; MMPs, matrix metalloproteinase; EGF, epidermal growth factor; LPC, Lysophosphatidylcholine; S1P, Sphingosine 1-phosphate.