FIG. 3.

Fully acknowledging inter-relationships between omics data on reduced genomic sets when deriving integrative solutions. (A) Per meaningful genomic concept, such as a gene, create a network of inter-relationships between omics elements “mapped” to that concept. (B) Represents the concept-based integrated data by using kernel-based principal components, where the kernel is chosen in such a way that the structure of the data is optimally captured. This leads to a new integrated concept-related signature for each individual in the sample. Each concept, therefore, gives rise to a new variable. The combined set of concepts (new variables) is submitted to subsequent analyses to obtain an integrated solution to the problem of interest.