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. 2020 Sep 4;11:1934. doi: 10.3389/fimmu.2020.01934

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Copyright © 2020 Wu, Xia, Li, Kang, Fang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA PVT1 enters EAE mice from M2-exos. (A) DiR labeled exosomes were traced in mice. It showed that exosomes mainly existed in liver and spleen 24 h after they entered the mice. Fluorescence also appeared in spinal cord of EAE mice; (B,C) Relative PVT1 expression in spinal cord of EAE mice with different treatment detected by RT-qPCR. Compared with the blank group, ***p < 0.001; compared with the EAE group, ##p < 0.01, ###p < 0.001. Data in (B) are analyzed with one-way ANOVA, and Tukey's multiple comparisons test was utilized for post hoc test. Data in (C) were analyzed by the t-test n = 6.