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. 2020 Sep 4;11:1934. doi: 10.3389/fimmu.2020.01934

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Copyright © 2020 Wu, Xia, Li, Kang, Fang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SOCS5 alleviates EAE symptoms by inhibiting pro-inflammatory response of Th17 cells through the JAKs/STAT3 pathway. (A) Clinical scores of EAE mice with different treatment; (B) Levels of JAKs/STAT3 pathway-related proteins and their phosphorylation levels in EAE mice detected by western blot analysis; vs. the blank group, ***p < 0.001; compared with the EAE group, #p < 0.05, ##p < 0.01, ###p < 0.001; (C,D) Detection of Treg and Th17 cells in spinal cord cells and splenocytes by flow cytometry; compared with the EAE group, *p < 0.05, **p < 0.01, ***p < 0.001; (E) Detection of inflammatory factors in spinal cord cells by ELISA; compared with the EAE group, *p < 0.05, **p < 0.01, ***p < 0.001. Data are analyzed with two-way ANOVA, and Tukey's multiple comparisons test was utilized for post hoc test n = 6.