Table 3. Stratification analysis for ER negative and PR negative associations between selected IL-12 signaling SNPs and BC risk in Puerto Rican women (n = 80).
| Gene | SNP | Genetic model | P value unstratified | Crude OR stratified (95% CI) | P value | Adjusted OR stratified1(95% CI) | P value | Adjusted OR stratified2(95% CI) | P value |
|---|---|---|---|---|---|---|---|---|---|
| IL12RB1 | rs401502 | Recessive | 0.009 | 2.92 (1.08–7.19) | 0.02 | 3.54 (1.28–9.04) | 0.01 | 4.14 (1.35–11.82) | 0.009 |
| STAT4 | rs3024896 | Dominant | 0.07 | 0.58 (0.37–0.99) | 0.05 | 0.58 (0.32–1.00) | 0.06 | 0.47 (0.22–0.92) | 0.04 |
| Additive | 0.08 | 0.59 (0.35–0.95) | 0.04 | 0.59 (0.34–0.97 | 0.05 | 0.46 (0.23–0.86) | 0.02 | ||
| rs3821236 | Dominant | 0.08 | 0.59 (0.36–0.95) | 0.03 | 0.59 (0.55–0.97) | 0.04 | 0.62 (0.34–1.11) | 0.11 | |
| IFNG | rs2069705 | Additive | 0.30 | 1.34 (0.95–1.90) | 0.09 | 1.45 (1.01–2.09) | 0.04 | 1.48 (0.97–2.26) | 0.07 |
| Recessive | 0.29 | 1.79 (0.97–3.18) | 0.05 | 2.15 (1.15–3.91) | 0.01 | 2.35 (1.14–4.66) | 0.02 |
OR: Odds ratio; CI: confidence interval; ER: Estrogen receptor; PR: progesterone receptor; neg: negative. 1Adjusted for Age and Educational level; 2Adjusted for Age, Educational level, ERT and Breastfeeding duration.