Table 4. Haplotype association with BC risk of selected IL-12 signaling gene SNPs.
Gene | |||||||
---|---|---|---|---|---|---|---|
IL12B | rs3212227 | rs2546892 | rs2569254 | rs3181216 | rs730691 | Frequency | OR (95% CI); pvalue |
1 | T | G | C | A | T | 0.27 | Ref. |
2 | G | G | C | A | T | 0.13 | 0.62 (0.42–0.91); 0.01 |
IL12RB1 | rs401502 | rs3761041 | rs404733 | rs438421 | Frequency | OR (95% CI); pvalue | |
1 | C | C | A | A | 0.29 | Ref. | |
2 | C | C | T | G | 0.25 | 1.36 (1.04–1.78); 0.03 | |
3 | C | T | A | G | 0.02 | 2.97 (1.04–8.51); 0.04 | |
STAT4 | rs10168266 | rs4274624 | rs925847 | Frequency | OR (95% CI); pvalue | ||
1 | C | C | T | 0.49 | Ref. | ||
2 | T | T | C | 0.24 | 0.57 (0.39–0.84); 0.004 |
OR: Odds ratio; CI: confidence interval.