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. 2020 Jun 30;8(2):71–79. doi: 10.2478/jtim-2020-0012

Figure 2.

Figure 2

Classification of the HECT E3 family. The family of HECT E3. All members of the HECT E3 family are characterized by the C-terminal HECT domain, which consists of approximately 350 amino acid residues and represents the catalytic domain. The NEDD4 subfamily has nine members that are characterized by an N-terminal C2 domain and the presence of several WW domains. The HERC family comprises six members, which are characterized by the presence of one or several RLD domains. Members of other HECT E3 subfamily are characterized by the notion that they contain neither RLDs nor WW domains.