Table 5.
Sensitivity and Specificity of Image Evaluation for RW-ROP Using Various Analysis Approaches
| Analysis Approach | Sensitivity | Specificity | ||||||
|---|---|---|---|---|---|---|---|---|
| Per-Eye Analysis | N | Estimate | 95% CI | Width of 95% CI | N | Estimate | 95% CI | Width of 95% CI |
| Naïve approach: normal approximation | 49 | 83.7% | 73.3–94.0% | 20.7% | 151 | 86.8% | 81.4–92.2% | 10.8% |
| Naïve approach: exact method | 49 | 83.7% | 70.3–92.7% | 22.4% | 151 | 86.8% | 80.3–91.7% | 11.4% |
| GEE | 49 | 83.7% | 69.0–92.2% | 23.2% | 151 | 86.8% | 79.3–91.8% | 12.5% |
| Cluster bootstrap | 49 | 84.4% | 70.8–94.7% | 23.9% | 151 | 87.0% | 80.6–92.6% | 11.6% |
| Left eye only* | 26 | 80.8% | 60.7–95.9% | 35.2% | 74 | 89.2% | 79.8–95.2% | 25.4% |
| Right eye only* | 23 | 87.0% | 66.4–97.2% | 30.8% | 77 | 84.4% | 74.4–91.7% | 17.3% |
| Per-infant analysis* | 29 | 96.6% | 82.2–99.9% | 17.7% | 71 | 85.9% | 77.8–94.0% | 16.2% |
*
Confidence interval was calculated using Clopper-Pearson exact method.