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. 2020 Sep 4;14:572013. doi: 10.3389/fnana.2020.572013

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Copyright © 2020 Schellino, Boido and Vercelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selective vulnerability of Onuf’s MNs. (A) Onuf’s nucleus is affected in several neurodegenerative diseases, such as Parkinson’s disease (PD) and multiple system atrophy (MSA) Parkinsonism, the progressive supranuclear palsy (PSP), the Shy-Drager-Syndrome, and Fabry’s disease. Onuf’s MNs are also degenerating in aging-related pathologies, leading, for instance, to urinary incontinence. (B) On the contrary, Onuf’s nucleus is spared in certain neurodegenerative diseases where, conversely, somatic MNs are degenerating: for instance, Onuf’s MNs are preserved in amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and duchenne muscular dystrophy (DMD). Dotted lines represent dying/affected MNs.