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Epac1 regulates AMPK phosphorylation in the retina. Epac1 floxed and cdh5/Epac1 Cre mice (A) and diabetic Epac1 floxed and cdh5/Epac1 Cre mice (B) were used to determine if Epac1 regulates phosphorylation of AMPK in whole retinal lysates in normal and diabetic mice. *P < 0.05 versus Epac1 floxed. Data are mean ± SEM (n = 7).
