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. 2020 Sep 4;8:536. doi: 10.3389/fped.2020.00536

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Copyright © 2020 Park, Shrivastava, Zhang, Pollok, Finkbeiner, Gibb, Ly and Illek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relation between ex vivo CFTR current measurements and clinical sweat chloride concentrations. Official standards for CF diagnostics based on sweat chloride are shown on the right. ΔI_CFTR is presented as mean ± SE values of CFTR inhibitor-sensitive current recorded in forskolin plus VX-770 stimulated cells without CFTR corrector treatment. A relation between the two measures appears significant by Pearson correlation with r = −0.953, p = 0.003, normality passed (Shapiro-Wilk), p = 0.917.