Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;8(2):e000638. doi: 10.1136/jitc-2020-000638

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Schematic summary. Soluble tumor-derived signals change the metabolic and functional characteristics of macrophages by induction of glycolysis and fatty acid biosynthesis leading to an enrichment of phospholipids and sphingomyelins. These metabolic features contribute to cytokine and ROS responses in tumor-induced macrophages, which are associated with a protumoral phenotype. DAG, diacylglyceride; FA, fatty acid; PC, phosphatidylcholines; PE, phosphatidylethanolamines; PI, phosphatidylinositol; PS, phosphatidylserine; ROS, reactive oxygen species; SM, sphingomyelins.