Table 1.
Patient | Gender | Age | BCR-ABL (%) | Breakpoint | |||||
---|---|---|---|---|---|---|---|---|---|
Untreated group | |||||||||
1 | M | 61 | 92 | b2a2 | |||||
2 | M | 52 | 100 | b2a2 | |||||
3 | M | 35 | 100 | b2a2 | |||||
4 | F | 54 | 100 | b2a2 | |||||
5 | M | 46 | 73 | b3a2 | |||||
6 | M | 72 | 100 | b2a2 | |||||
7 | F | 80 | 100 | b3a2 | |||||
8 | M | 67 | 100 | b3a2 | |||||
9 | M | 59 | 40 | b2a2 | |||||
10 | M | 60 | 82 | b2+b3 | |||||
11 | F | 52 | 100 | b3a2 | |||||
12 | M | 37 | 100 | b3a2 | |||||
13 | F | 53 | 100 | b3a2 | |||||
14 | M | 72 | 100 | b3a2 | |||||
Patients | Gender | Age | HSCT indication | Source | DAT | BCR-ABL (%) | Breakpoint | Mutation | Follow up |
Hematopoietic stem cell transplantation group | |||||||||
1 | M | 37 | Disease progression | BM | 224 | 1.60 | b2a2 | Absence | Relapsed |
2 | F | 44 | Failed therapy | BM | 231 | 1,20 | b3a2 | Absence | Relapsed |
3 | F | 03 | Disease progression | BM | 208 | 0.20 | b3a2 | _ | Relapsed |
4 | F | 63 | FC | BM | 1569 | 0.20 | b3a2 | Absence | Relapsed |
5 | M | 37 | Failed therapy | BM | 110 | 0.50 | b2a2 | _ | Relapsed |
6 | M | 43 | FC | BM | 2450 | 0.30 | b3a2 | _ | MMR |
7 | M | 48 | Disease progression | PBSC | 80 | 0.75 | b3a2 | Absence | MMR |
8 | M | 35 | Failed therapy | BM | 2352 | 0.03 | b3a2 | Absence | Relapsed |
9 | M | 42 | Failed therapy | PBSC | 3561 | 0.01 | b2a2 | _ | Relapsed |
10 | F | 42 | Disease progression | PBSC | 3708 | 0.01 | b3a2 | _ | MMR |
11 | F | 56 | FC | BM | 3932 | 0.03 | b2a2 | Absence | MMR |
12 | M | 32 | FC | PBSC | 3242 | 0.08 | b2a2 | _ | Relapsed |
13 | M | 21 | FC | BM | 1949 | 0.30 | b3a2 | Absence | Relapsed |
14 | M | 58 | Disease progression | BM | 41 | 0.02 | b2a2 | _ | MMR |
DAT, days after transplantation; BM, bone marrow; PBSC, peripheral blood stem cell; (-), BCR-ABL mutation test was not performed; MMR, Major molecular response (BCR-ABL1 transcript level ≤ 0.1%).