Fig. 7.
The influence of an intracellular lysine cluster on the intracellular pH (pHi) dependence of Slc4a11 at extracellular pH (pHe) 8.50. Three Slc4a11 mutants K343Q, SSQ, and pre-TM1-del (per Fig. 6D) were tested for their response to changes in intracellular pH (pHi). A–C: a sampling of current-voltage (I-V) plots gathered from a representative mutant-Slc4a11-expressing cell during the experiments equivalent to that shown in Fig. 2A. D–F: the relationship between pHi and membrane conductance (Gm) for a greater number of mutant-Slc4a11-expressing oocyte calculated from all of the I-V plots gathered for each cell. G–I: each Slc4a11 trace from Fig. 6, D–F, is shown here normalized to its own maximum conductance. Vm, membrane potential.