Fig. 6.
SLC26A4 (pendrin) contributes to TNFα+IL-17-induced airway surface liquid (ASL) alkalinization. A and B: siRNA directed against SLC26A4 was used to knock down expression, and pH of ASL (pHASL) was measured after treatment with either vehicle or TNFα+IL-17 for 24 h (n = 6). Individual data points in each group represent epithelia from a different donor. Bars indicate means ± SD. Groups were compared with paired Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001. NC, negative control; NS, not significant.