Fig. 1.

Fold change of bile acids over time. Fold changes in concentrations of unconjugated primary bile acids (A), conjugated primary bile acids (B), and unconjugated secondary bile acids (C) and ratio of total conjugated (conjugated primary and conjugated secondary bile acids) to unconjugated secondary bile acids (D) were calculated for each subject relative to the subject’s baseline, with concentrations measured in μmol/g dry stool weight. Data shown are means ± SE. See Table 1 for bile acid groupings. The sample numbers for fold change in the vancomycin (VAN) group were 19 on day 10 (D10), 14 on day 25 (D25), and 10 on day 40 (D40); the numbers in the ridinilazole (RID) group were 21 on day 10 (D10), 18 on day 25 (D25), and 17 on day 40 (D40). ##Significant differences from baseline within each treatment group by Wilcoxon signed-rank test (P < 0.001); **P < 0.001 and ***P < 0.0001, significant differences between treatment groups by Wilcoxon rank-sum test.