Table 1.

Effect of pregnancy on hepatic mRNA expression of key bile acid homeostasis genes

	NC		CA		OCA		CA + OCA
	NP	P	NP	P	NP	P	NP	P
Shp	2.06 ± 0.35	0.74 ± 0.14*	3.36 ± 0.63	2.59 ± 0.49	1.78 ± 0.39	1.12 ± 0.19	3.46 ± 0.49	2.15 ± 0.21*
Cyp7a1	1.37 ± 0.37	1.59 ± 0.27	0.004 ± 0.001	0.004 ± 0.002	0.66 ± 0.21	0.14 ± 0.02*	0.006 ± 0.0023	0.005 ± 0.001
Ntcp	0.77 ± 0.21	0.19 ± 0.05*	0.29 ± 0.06*	0.13 ± 0.02*	0.36 ± 0.03	0.15 ± 0.01*	0.28 ± 0.05	0.14 ± 0.01*
Bsep	1.74 ± 0.38	1.02 ± 0.21	2.78 ± 0.36	1.98 ± 0.25	2.05 ± 0.37	1.05 ± 0.17*	2.62 ± 0.34	1.76 ± 0.15*
Mrp3	1.31 ± 0.12	0.23 ± 0.13*	2.68 ± 0.41	0.59 ± 0.11*	1.07 ± 0.17	0.09 ± 0.01*	2.28 ± 0.29	0.63 ± 0.08*
Mrp4	1.17 ± 0.12	1.25 ± 0.40	4.87 ± 0.21	3.11 ± 0.48*	1.56 ± 0.28	0.63 ± 0.11*	4.58 ± 0.61	3.412 ± 0.34

Data are presented as means ± SE; n = 3–6 mice. CA, cholic acid; NC, normal chow diet; NP, nonpregnant; OCA, obeticholic acid; P, pregnant. Relative mRNA expression of target genes in NP and P females fed the same diet.

^*P ≤ 0.05 vs. NP females fed the same diet.